Stephen Hughes, Ph.D.  – Director, HIV Drug Resistance Program; Chief, Retroviral Replication Laboratory; and Head, Vector Design and Replication Section, National Cancer Institute

Nathanael Gray, Ph.D.  – Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School 

Session 1 – AM

9:00     Welcome and Overview of the Day – Celia Schiffer, PhD, co-founder of Institute for Drug Resistance

9:15     Marie Pierre De Bethune, Ph.D. – Vice President External Innovation at Tibotec, “Targeting drug resistance in HIV - from bench to clinic with darunavir and etravirine”

9:45     Stephen Hughes, Ph.D.  – Director, HIV Drug Resistance Program; Chief, Retroviral Replication Laboratory; and Head, Vector Design and Replication Section, National Cancer Institute, “ HIV-1 RT Drug Resistance and Drug Development”

10:15   Coffee Break & Posters

10:45   Nathanael Gray, Ph.D. – Assistant Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, “Three Different Strategies for Overcoming Kinase Inhibitor Resistance”

11:15 Sarah Fortune, M.D. - Assistant Professor of Immunology and Infectious Diseases, Harvard School of Public Health, “Biologic determinants of mutability and drug resistances in Mycobacterium tuberculosis”

11:45   Lunch & Posters

Session 2 – PM

1:00     Sharon Ladin, Director, Antibiotics and Innovation Project, The Pew Charitable Trusts “Advocating for Policies that Prime the Antibiotics Pipeline”

1:30     Stephen Becker, M.D. – Senior Program Officer Infectious Diseases Development, Gates Foundation, “Novel Initiatives for Addressing Drug Resistance in HIV from an NGO Perspective”

2:00    Coffee Break

2:15     Drug Resistance Policy Roundtable Discussion – Moderator, Peg Riley, PhD, co-founder Institute for Drug Resistance

Short Poster Presentations

3:15     Chaoping Chen, Ph.D. Assistant Professor of Biochemistry and Molecular Pharmacology Colorado State University, “Shooting at an Old Target from New Angle: Understanding HIV Protease Autoprocessing for Novel Therapeutic Development”

3:30    Liem Nguyen, Ph.D. Assistant Professor of Molecular and Microbiology, Case Western School of Medicine.  “Starving Popeye:  Senstizing Mycobacterium tuberculosis”

3:45    Yuk-Ching Tse-Dinh, Ph.D. Professor, Biochemistry and Molecular Biology, New York Medical College. “Targeting topoisomerase I for treatment of MDR Gram-negatives and TB”

4:00    Suphan Bakkal, Ph.D. Post-Doctoral Researcher, University of Massachusetts Amherst.   “The Role of Bacteriocins in Mediating Interactions of BacterialIisolates from Cystic Fibrosis Patients”

4:15    Thomas Keating, Ph.D. Principal Scientist, Infection iMed, Enzymology & In Vitro Screening, Astrazeneca Pharmaceuticals. “Resistance Mechanism in a Novel Target: Helicobacter pylori MurI”

4:30     Closing and Wrap Up – Tien Bui, Director, Institute for Drug Resistance

4:45     Posters & Wine Networking